New research reveals that individuals who stop using blockbuster slimming jabs like Mounjaro or Wegovy tend to recover reduced body mass much more quickly than those who end traditional lifestyle programs.
Published data in a leading medical journal demonstrates that while obese individuals often shed a large proportion of their body weight while on the medication, the mass comes back at an average rate of 0.8 kg per month upon discontinuation.
"People purchasing these medications should be cognizant of the danger of fast rebound weight gain when the medication concludes," stated researcher Dr. Susan Jebb.
Such speed of recovery means a return to starting weight within about one and a half years.
Weighing Therapies
The analysis, which looked at dozens of studies involving over 9,000 of participants, contrasted the results of GLP-1 agonists with older methods.
The team point out that people who lose weight through diet and exercise generally have a slower weight regain—perhaps 100 grams monthly—once they finish.
The Reason for the Quick Rebound
Doctors suggest the mode of action of the jabs explains the amplified regain.
These medications copy a natural hormone called glucagon-like peptide-1, which controls feelings of fullness.
"Artificially providing GLP-1 levels far above than the body's typical production may cause the system to produce less of its endogenous hormone, and may also diminish sensitivity to its actions," explained Dr. Adam Collins, a nutrition expert.
"Stopping of this hormone supplement results in appetite is uncontrolled, making overeating a significant risk."
An Ongoing Issue?
The NHS advise the jabs for people with weight-linked medical conditions, accompanied by recommended diet and exercise modifications.
Many experts say that, considering the significant potential of relapse, the treatment might need to be long-term.
This opinion is supported by pharmaceutical companies, who note that the results "underscore the chronic nature of excess weight," similar to managing diseases like diabetes.
User Accounts
Users who have discontinued the jabs explain a powerful resurgence of hunger.
"I experienced a switch that goes on and I was suddenly ravenous," described one woman.
The struggle is compounded if users have not adopted lasting dietary or behavioural changes during treatment.
Widespread Interest
Figures show that a significant number of adults in the UK have used weight-loss jabs in the past year, with demand continuing to grow.
- Use is higher among females than men.
- The middle-aged demographic shows the highest usage rates.
- A large proportion obtain the medications through private healthcare rather than the NHS.
Finally, researchers emphasize that while these medications are powerful agents for shedding pounds, they are not a standalone solution and maintained weight loss hinges on ongoing lifestyle changes.
